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3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Featured Image
  • 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
  • 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

short description:

Chemical & Physical Properties

5-morpholin-4-yl-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one is used as an intermediate for apixaban.

Apixaban is an oral selective activation factor X inhibitor that can prevent thrombosis, but the adverse effects of bleeding are lower than that of the old drug warfarin. It is used for thrombosis prevention in patients who have undergone hip or knee replacement surgery.

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Products under patent are offered for R & D purpose only.

  • Appearance : white to off-white powder
  • Assay : ≥99.0%
  • Density: 1.357 g/cm3
  • Boiling Point: 506.5℃ at 760 mmHg
  • Flash Point: 260.1℃

    • Product Detail

    Product Tags

    Product Description

    Product Name  5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone CAS NO:503615-03-0
     Synonyms 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one;
    CAS NO  503615-03-0
    Molecular Formula C15H17N3O4
    Molecular Weight  303.313
    EINECS NO  N/A
    MDL NO  N/A

    Application

    Use: The apixaban intermediate in the A

    3- (Morpholinyl) -N- (4-nitrophenyl) -5,6-dihydropyridin-2-one is a reagent used for the synthesis of 4,5-dehydro Apixaban (D229385), which is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of the coagulation factor Xa. It is a potential novel oral coagulation agent that can be used to prevent VTE in total hip, knee replacement orthopedic surgery, and to treat stroke in patients with venous thromboembolic disease or atrial fibrillation.

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    6.OEM,ODM, custom design /logo/ brand, packaging are available.
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    2）
    1.Terms of Payment : DA 90 days. TT In Advance L/C: At sight
    2.Capacity of Months : 1MTS
    3.Custom information : As Customer
    4. Way of Loading : By sea, by Air .
    5.Port of shipment : Shang Hai . Ning Bo , Qingdao Tian Jing , Guangzhou .
    6.Package information: As factory or Customer Custom .
    7.Safety information : Not dangerous Goods

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