On April 15, 2022, the pilot production of Lecardipine hydrochloride main ring was completed at one time, and the current production capacity is 5Mt/ month.
English Name: Lercanidipine hydrochloride
Chemical name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-di phenylpropyl)methylamino]-l,l-dimethylethyl methyl ester hydrochloride.
CAS No: 132866-11-6
Application: For the treatment of Lecardipine hydrochloride medicine, it will not have adverse effect on blood glucose and lipid levels, and has a strong antihypertensive effect.
Market prospect：
There are more than 200 million hypertensive patients in China, and there are 10 million new hypertensive patients every year, most of which are not under control, resulting in a high incidence of hypertension complications such as stroke, and the annual death in China Among 3 million patients with cardiovascular disease,50% are related to hypertension, and the annual cost of cardiovascular disease treatment is about 309.8 billion yuan. The reason for the poor control is not only that patients' awareness of hypertension and its complications needs to be improved, but also that many patients who need to take lifelong medication have poor compliance and cannot take medication every day However, this also shows that the antihypertensive drug market has potential expansion. Compared with similar drugs, locarbodipine hydrochloride has strong vascular selectivity. Its unique lipophilic property makes it slow and lasting antihypertensive effect The atherogenic effect, especially suitable for hypertension patients with atherosclerosis, has high clinical application value and broad market prospect.
Pharmacological action：
Lecardipine is a new generation of dihydropyridine calcium channel group hysteresis agent, with strong vascular selectivity, gentle effect, strong antihypertensive effect, long action time, less negative inotropic effect and so on. In vitro studies have found that locarbodipine has a direct relaxation effect on vascular smooth muscle, and therefore has a strong antihypertensive effect in vivo, but has little effect on heart rate and cardiac output. Because of its large hydrophobic gene and strong lipid solubility, locarbodipine is rapidly distributed to tissues and organs after entering the body, closely binding to vascular smooth muscle cell membrane, and releasing slowly. Therefore, although the serum of this drug has a short elimination period of half-failure, its effect is long-lasting.
Post time: Apr-15-2022